Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins.

@article{Shin2005MultiplePO,
  title={Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins.},
  author={Chanseok Shin and Frida Esther Kleiman and James L Manley},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 18},
  pages={8334-43}
}
The SR protein SRp38 is a general splicing repressor that is activated by dephosphorylation during mitosis and in response to heat shock. Here we describe experiments that provide insights into the mechanism by which SRp38 functions in splicing repression. We first show that SRp38 redistributes and colocalizes with snRNPs, but not with a typical SR protein, SC35, during mitosis and following heat shock. Supporting the functional significance of this association, a micrococcal nuclease-sensitive… CONTINUE READING

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