Multiple primary cancers in families with Li-Fraumeni syndrome.

@article{Hisada1998MultiplePC,
  title={Multiple primary cancers in families with Li-Fraumeni syndrome.},
  author={Michie Hisada and Judy E Garber and Claire Y. Fung and Joseph F. Jr. Fraumeni and Frederick P. Li},
  journal={Journal of the National Cancer Institute},
  year={1998},
  volume={90 8},
  pages={606-11}
}
BACKGROUND Li-Fraumeni syndrome is a dominantly inherited disorder characterized by early-onset breast cancer, sarcomas, and other cancers in children and young adults. Members of families with this syndrome also develop multiple primary cancers, but the frequency is unknown. To approach this issue, we quantified the incidence of second and third primary cancers in individuals from 24 Li-Fraumeni kindreds originally diagnosed with cancer during the period from 1968 through 1986. METHODS The… CONTINUE READING
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