Multiple positive and negative 5' regulatory elements control the cell-type-specific expression of the embryonic skeletal myosin heavy-chain gene.

@article{Bouvagnet1987MultiplePA,
  title={Multiple positive and negative 5' regulatory elements control the cell-type-specific expression of the embryonic skeletal myosin heavy-chain gene.},
  author={P F Bouvagnet and Emanuel E. Strehler and George E. White and M A Strehler-Page and Bernardo Nadal-Ginard and Vijak Mahdavi},
  journal={Molecular and cellular biology},
  year={1987},
  volume={7 12},
  pages={4377-89}
}
To identify the DNA sequences that regulate the expression of the sarcomeric myosin heavy-chain (MHC) genes in muscle cells, a series of deletion constructs of the rat embryonic MHC gene was assayed for transient expression after introduction into myogenic and nonmyogenic cells. The sequences in 1.4 kilobases of 5'-flanking DNA were found to be sufficient to direct expression of the MHC gene constructs in a tissue-specific manner (i.e., in differentiated muscle cells but not in undifferentiated… CONTINUE READING

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