Multiple polymorphisms, but no mutations, in the WAF1/CIP1 gene in human brain tumours.


The cyclin kinase inhibitor WAF1/CIP1, also termed CDKN1, mediates p53-induced cell cycle arrest in response to DNA damage. This property makes it an attractive tumour-suppressor candidate for a p53-associated tumour-suppressor gene. In order to investigate the role of WAF1/CIP1 in the pathogenesis of primary human brain tumours we performed single-stranded… (More)
DOI: 10.1038/bjc.1995.491


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