Multiple pituitary and ovarian defects in Krox-24 (NGFI-A, Egr-1)-targeted mice.

  title={Multiple pituitary and ovarian defects in Krox-24 (NGFI-A, Egr-1)-targeted mice.},
  author={Piotr Topilko and Sylvie Schneider-Maunoury and Giovanni Levi and Alain Trembleau and Danielle Gourdji and M A Driancourt and Ch Venkateswara Rao and Patrick Charnay},
  journal={Molecular endocrinology},
  volume={12 1},
The zinc finger transcription factor Krox-24 (NGFI-A, Egr-1) is encoded by an immediate-early serum response gene expressed in various physiological situations and tissues. To investigate its function, we have created a null allele. Mice homozygous for the mutation have a reduced body size, and both males and females are sterile. These phenotypes were related to defects in the anterior pituitary of both sexes and in the ovary. In the pituitary, two cell lineages expressing Krox-24 are… CONTINUE READING

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