Multiple pilocarpine-induced status epilepticus in developing rats: a long-term behavioral and electrophysiological study.

@article{Santos2000MultiplePS,
  title={Multiple pilocarpine-induced status epilepticus in developing rats: a long-term behavioral and electrophysiological study.},
  author={Neide dos Santos and Ricardo Henrique Marques and Lu{\'i}s. M. Correia and Rita Sinigaglia-Coimbra and Lineu Calderazzo and Em{\'i}lio Rafael Garrido Sanabria and Esper Abr{\~a}o Cavalheiro},
  journal={Epilepsia},
  year={2000},
  volume={41 Suppl 6},
  pages={S57-63}
}
PURPOSE Animal models are useful for the study of status epilepticus (SE)-induced epileptogenesis and neurological sequelae, especially during early brain development. Here, we show several permanent abnormalities in animals subjected to multiple SE during early development. METHODS Wistar pup rats (7 to 9 days old) were subjected to three consecutive episodes of SE induced by systemic pilocarpine injections. To study the long-lasting consequences of early-induced SE. chronic… CONTINUE READING

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