Multiple phospholipase activation by OX1 orexin/hypocretin receptors

Abstract

We investigated coupling of OX1 receptors to phospholipase activation and diacylglycerol generation in Chinese hamster ovary (CHO) cells using both biochemical and fluorescence “real-time” methods. The results indicate that at lowest orexin-A concentrations (highest potency), diacylglycerol generated results from phospholipase D activity. At 10–100-fold… (More)
DOI: 10.1007/s00018-008-8206-z

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