Multiple phenotype modeling in gene-mapping studies of quantitative traits: power advantages.

@article{Allison1998MultiplePM,
  title={Multiple phenotype modeling in gene-mapping studies of quantitative traits: power advantages.},
  author={David B. Allison and Bonnie Thiel and Pamela St. Jean and Robert C. Elston and Marie C Infante and Nicholas J. Schork},
  journal={American journal of human genetics},
  year={1998},
  volume={63 4},
  pages={1190-201}
}
Genomewide searches for loci influencing complex human traits and diseases such as diabetes, hypertension, and obesity are often plagued by low power and interpretive difficulties. Attempts to remedy these difficulties have typically relied on, and have promoted the use of, novel subject-ascertainment schemes, larger sample sizes, a greater density of DNA markers, and more-sophisticated statistical modeling and analysis strategies. Many of these remedies can be costly to implement. We… CONTINUE READING

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