Multiple personalities of the RNA polymerase active centre.

  title={Multiple personalities of the RNA polymerase active centre.},
  author={Nikolay Zenkin},
  volume={160 Pt 7},
  • N. Zenkin
  • Published 1 July 2014
  • Biology
  • Microbiology
Transcription in all living organisms is accomplished by highly conserved multi-subunit RNA polymerases (RNAPs). Our understanding of the functioning of the active centre of RNAPs has transformed recently with the finding that a conserved flexible domain near the active centre, the trigger loop (TL), participates directly in the catalysis of RNA synthesis and serves as a major determinant for fidelity of transcription. It also appears that the TL is involved in the unique ability of RNAPs to… 

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Role of the RNA polymerase trigger loop in catalysis and pausing

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