Multiple pathways suppress telomere addition to DNA breaks in the Drosophila germline.

@article{Beaucher2012MultiplePS,
  title={Multiple pathways suppress telomere addition to DNA breaks in the Drosophila germline.},
  author={Michelle L Beaucher and Xiao-feng Zheng and Flavia L Amariei and Yikang S Rong},
  journal={Genetics},
  year={2012},
  volume={191 2},
  pages={407-17}
}
Telomeres protect chromosome ends from being repaired as double-strand breaks (DSBs). Just as DSB repair is suppressed at telomeres, de novo telomere addition is suppressed at the site of DSBs. To identify factors responsible for this suppression, we developed an assay to monitor de novo telomere formation in Drosophila, an organism in which telomeres can be established on chromosome ends with essentially any sequence. Germline expression of the I-SceI endonuclease resulted in precise telomere… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Similar Papers

Loading similar papers…