Multiple opiate receptors: phylogenetic differences

@article{Buatti1981MultipleOR,
  title={Multiple opiate receptors: phylogenetic differences},
  author={Mary C. Buatti and Gavril W. Pasternak},
  journal={Brain Research},
  year={1981},
  volume={218},
  pages={400-405}
}
Both the levels and types of binding sites for opiates and enkephalins appear to be different between species. The most dramatic differences are seen between rats, which have significant levels of both high and low affinity sites, and goldfish, which have only low affinity sites. Binding to both high and low affinity sites is easily displaced by low concentrations of morphine and D-Ala2-D-Leu5-enkephalin, suggesting that both represent relevant receptor sites. 
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Multiple Morphine and Enkephalin Receptors: Biochemical and Pharmacological Aspects
  • G. Pasternak
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • 1986
TLDR
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TLDR
Highly selective antagonists for mu-, delta- and kappa-opioid receptors yielded nearly identical K(i) values against [3H]naloxone in the amphibian Rana pipiens. Expand
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The complexity of opioid binding studies in recent years has increased dramatically as a result of the identification of multiple subclasses of receptors. Early studies performed prior to the reportExpand
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The selectivity and binding characteristics in the pigeon brain of three such ligands were examined by in vitro receptor binding techniques and found to be similar to those reported in previous studies on mammalian species. Expand
Biochemical and pharmacological evidence for opioid receptor multiplicity in the central nervous system.
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Biochemical experiments now support the concept of a common high affinity site for opiates and opioid peptides in the central nervous system, supported by the unique opioid meptazinol, which selectively bound to mu 1 sites. Expand
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