Multiple oncogenic roles of nuclear β-catenin

@article{Kumar2017MultipleOR,
  title={Multiple oncogenic roles of nuclear β-catenin},
  author={Raju Kumar and Murali Dharan Bashyam},
  journal={Journal of Biosciences},
  year={2017},
  volume={42},
  pages={695-707}
}
Abstractβ-Catenin is essential for embryonic development and required for cell renewal/regeneration in adult life. Cellular β-catenin exists in three different pools: membranous, cytoplasmic and nuclear. In this review, we focus on functions of the nuclear pool in relation to tumorigenesis. In the nucleus, β-catenin functions as both activator and repressor of transcription in a context-dependent manner. It promotes cell proliferation and supports tumour growth by enhancing angiogenesis… CONTINUE READING
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