Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides.

@article{Fairman1993MultipleOS,
  title={Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides.},
  author={Robert Fairman and R K Beran-Steed and S. J. Anthony-Cahill and James D. Lear and Walter F. Stafford and William F. DeGrado and Pamela A. Benfield and Stephen L. Brenner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 22},
  pages={10429-33}
}
To study the protein-protein interactions that allow Id, a negative regulator of cell differentiation, to inhibit the DNA-binding activities of MyoD and E47, we have synthesized peptides corresponding to the helix-loop-helix domains of MyoD, E47, and Id. We show that Id preferentially inhibits the sequence-specific DNA-binding activity of MyoD, a muscle-specific protein, as compared to E47, a more ubiquitous protein. The Id helix-loop-helix domain itself forms stable tetramers, and its… CONTINUE READING

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