Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides.

  title={Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides.},
  author={Robert Fairman and R K Beran-Steed and S. J. Anthony-Cahill and James D. Lear and Walter F. Stafford and William F. DeGrado and Pamela A. Benfield and Stephen L. Brenner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={90 22},
To study the protein-protein interactions that allow Id, a negative regulator of cell differentiation, to inhibit the DNA-binding activities of MyoD and E47, we have synthesized peptides corresponding to the helix-loop-helix domains of MyoD, E47, and Id. We show that Id preferentially inhibits the sequence-specific DNA-binding activity of MyoD, a muscle-specific protein, as compared to E47, a more ubiquitous protein. The Id helix-loop-helix domain itself forms stable tetramers, and its… CONTINUE READING

From This Paper

Topics from this paper.
14 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 14 extracted citations

Similar Papers

Loading similar papers…