Multiple nuclear receptor signaling pathways mediate the actions of synthetic progestins in target cells

@article{Moore2012MultipleNR,
  title={Multiple nuclear receptor signaling pathways mediate the actions of synthetic progestins in target cells},
  author={N. Moore and T. Hickey and L. Butler and W. Tilley},
  journal={Molecular and Cellular Endocrinology},
  year={2012},
  volume={357},
  pages={60-70}
}
Synthetic progestins are used clinically to treat a variety of women's health issues. Although progestins are designed to signal through the progesterone receptor (PR) to elicit specific pharmacological effects, they can also variably bind to and influence the activity of other nuclear receptors within target tissues, particularly the androgen and glucocorticoid receptors and, in some cases, they regulate mineralocorticoid and estrogen receptors. This article reviews current knowledge on… Expand
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