Multiple novel classes of APRIL-specific receptor-blocking peptides isolated by phage display.

Abstract

A proliferation-inducing ligand (APRIL) is a member of the tumor necrosis factor (TNF) ligand superfamily and has a proliferative effect on both normal and tumor cells. The TNF family receptors (B-cell maturation antigen (BCMA), transmembrane activator and CAML-interactor (TACI), and BAFF receptor-3 (BR3)) for APRIL and the closely related ligand, B-cell… (More)
DOI: 10.1016/j.jmb.2009.11.041

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