Multiple novel alterations in Kit tyrosine kinase in patients with gastrointestinally pronounced systemic mast cell activation disorder.

@article{Molderings2007MultipleNA,
  title={Multiple novel alterations in Kit tyrosine kinase in patients with gastrointestinally pronounced systemic mast cell activation disorder.},
  author={Gerhard J Molderings and Ulrich W. Kolck and Christian Scheurlen and Michael Br{\"u}ss and J{\"u}rgen Homann and Ivar von K{\"u}gelgen},
  journal={Scandinavian journal of gastroenterology},
  year={2007},
  volume={42 9},
  pages={
          1045-53
        }
}
OBJECTIVE Sequencing efforts to discover mutations in the tyrosine kinase Kit related to systemic mast cell disorders have so far been focused mainly on only a few of the 21 exons of the encoding gene c-kit, thus considerably limiting the possibility to quantitatively reveal pathogenetic relationships. The purpose of this study was to analyze and compare the total sequence of Kit tyrosine kinase at the level of the mRNAs obtained from patients with clear systemic signs of a pathologically… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 30 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Similar Papers

Loading similar papers…