Multiple newly identified loci associated with prostate cancer susceptibility

@article{Eeles2008MultipleNI,
  title={Multiple newly identified loci associated with prostate cancer susceptibility},
  author={Rosalind A. Eeles and Zsofia Kote-Jarai and Graham G. Giles and Ali Amin Al Olama and Michelle Guy and Sarah K Jugurnauth and Shani A. Mulholland and Daniel A. Leongamornlert and Stephen M. Edwards and Jonathan Morrison and Helen I. Field and Melissa C. Southey and Gianluca Severi and Jenny L. Donovan and Freddie C. Hamdy and David P. Dearnaley and Kenneth Ross Muir and Charmaine D. Smith and Melisa Bagnato and Audrey Ardern-jones and Amanda L. Hall and Lynne T. O'Brien and Beatrice N Gehr-Swain and Rosemary A. Wilkinson and Angela Cox and Sarah J. Lewis and Paul M. Brown and Sameer Jhavar and Malgorzata Tymrakiewicz and Artitaya Lophatananon and Sarah L Bryant and Alan Horwich and Robert A. Huddart and Vincent Khoo and Chris C. Parker and Christopher J Woodhouse and Alan Thompson and Timothy J. Christmas and Chris Ogden and Cyril Fisher and Charles Jamieson and Colin S Cooper and Dallas R. English and John L. Hopper and David E. Neal and Douglas F. Easton},
  journal={Nature Genetics},
  year={2008},
  volume={40},
  pages={316-321}
}
Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at ≤60 years or with a family history of disease, and 1,894 population-screened controls with… 

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TLDR
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Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

TLDR
The study is extended to evaluate promising associations in a second stage in which 43,671 SNPs are genotyped in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies.

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TLDR
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TLDR
On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled.

Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population

TLDR
Five new loci for prostate cancer susceptibility are reported here, at 5p15 (λ-corrected probability PGC = 3.9 × 10−18), GPRC6A/RFX6 (PGC = 1.6 ×10−12), 13q22 ( PGC = 2.8 × 10–10−9), C2orf43 (PGD = 7.5 × 10.–8) and FOXP4 (PGE = 7−8).

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

TLDR
These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.

Two Susceptibility Loci Identified for Prostate Cancer Aggressiveness

TLDR
A multistage, case-only genome-wide association study of prostate cancer cases identifies two loci associated with Gleason score, a pathological measure of disease aggressiveness, and the proximity of these loci to genes involved in vascular disease suggests potential biological mechanisms worthy of further investigation.

Identification of an aggressive prostate cancer predisposing variant at 11q13

TLDR
The results indicate that the intronic variant IVS6‐43A>G increases the familial and unselected prostate cancer risk in a Finnish population and contributes to the aggressive progression of the disease in a high‐penetrance manner.
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