Multiple neuroprotective mechanisms of minocycline in autoimmune CNS inflammation

@article{Maier2007MultipleNM,
  title={Multiple neuroprotective mechanisms of minocycline in autoimmune CNS inflammation},
  author={K. Maier and D. Merkler and J. Gerber and N. Taheri and R. Diem},
  journal={Neurobiology of Disease},
  year={2007},
  volume={25},
  pages={514-525}
}
  • K. Maier, D. Merkler, +2 authors R. Diem
  • Published 2007
  • Medicine
  • Neurobiology of Disease
  • Axonal destruction and neuronal loss occur early during multiple sclerosis, an autoimmune inflammatory CNS disease that frequently manifests with acute optic neuritis. Available therapies mainly target the inflammatory component of the disease but fail to prevent neurodegeneration. To investigate the effect of minocycline on the survival of retinal ganglion cells (RGCs), the neurons that form the axons of the optic nerve, we used a rat model of myelin oligodendrocyte glycoprotein (MOG)-induced… CONTINUE READING
    99 Citations
    Anti-inflammatory effects of FTY720 do not prevent neuronal cell loss in a rat model of optic neuritis.
    • 31
    N-methyl-D-aspartate receptor blockade is neuroprotective in experimental autoimmune optic neuritis.
    • 25
    • PDF
    Calpain inhibitor attenuated optic nerve damage in acute optic neuritis in rats
    • 40
    Combined treatment with atorvastatin and minocycline suppresses severity of EAE
    • 50
    • Highly Influenced
    Pivotal role of choline metabolites in remyelination.
    • 52
    • PDF
    Neuroprotective role of minocycline in co-cultures of human fetal neurons and microglia
    • 41
    Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma.
    • 228
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 69 REFERENCES
    Methylprednisolone Increases Neuronal Apoptosis during Autoimmune CNS Inflammation by Inhibition of an Endogenous Neuroprotective Pathway
    • 139
    • PDF
    Combined therapy with methylprednisolone and erythropoietin in a model of multiple sclerosis.
    • 126
    • PDF
    Glutamate excitotoxicity in a model of multiple sclerosis
    • 769
    • PDF
    Acute Neuronal Apoptosis in a Rat Model of Multiple Sclerosis
    • 212
    • PDF