Multiple neuroprotective mechanisms of minocycline in autoimmune CNS inflammation

  title={Multiple neuroprotective mechanisms of minocycline in autoimmune CNS inflammation},
  author={K. Maier and D. Merkler and J. Gerber and N. Taheri and R. Diem},
  journal={Neurobiology of Disease},
  • K. Maier, D. Merkler, +2 authors R. Diem
  • Published 2007
  • Medicine
  • Neurobiology of Disease
  • Axonal destruction and neuronal loss occur early during multiple sclerosis, an autoimmune inflammatory CNS disease that frequently manifests with acute optic neuritis. Available therapies mainly target the inflammatory component of the disease but fail to prevent neurodegeneration. To investigate the effect of minocycline on the survival of retinal ganglion cells (RGCs), the neurons that form the axons of the optic nerve, we used a rat model of myelin oligodendrocyte glycoprotein (MOG)-induced… CONTINUE READING
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