Multiple neuropeptides derived from a common precursor are differentially packaged and transported

@article{Fisher1988MultipleND,
  title={Multiple neuropeptides derived from a common precursor are differentially packaged and transported},
  author={Joseph Matthew Fisher and Wayne S. Sossin and Robert Newcomb and Richard Henry Scheller},
  journal={Cell},
  year={1988},
  volume={54},
  pages={813-822}
}
The ELH prohormone is proteolytically processed into at least nine peptides which govern egg-laying behavior in Aplysia. Quantitative immunocytochemistry demonstrates that peptides derived from the prohormone are packaged into distinct vesicle classes. Further experiments suggest the segregation occurs via a rapid initial proteolytic cleavage of the prohormone followed by sorting at the trans Golgi. Egg-laying hormone (ELH) immunoreactivity is localized to the cell body and processes, while bag… CONTINUE READING
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