Multiple myeloma patients with CKS1B gene amplification have a shorter progression-free survival post-autologous stem cell transplantation.

@article{Chang2006MultipleMP,
  title={Multiple myeloma patients with CKS1B gene amplification have a shorter progression-free survival post-autologous stem cell transplantation.},
  author={Hong Chang and Xiaoying Qi and Young Trieu and Wei Xu and Jocelyn C. Reader and Yi Ning and Donna E. Reece},
  journal={British journal of haematology},
  year={2006},
  volume={135 4},
  pages={486-91}
}
The prevalence and prognostic relevance of recurrent gains of CKS1B (cyclin kinase subunit 1B) gene at chromosome 1q21 region was investigated by interphase fluorescence in situ hybridisation in a cohort of 99 multiple myeloma (MM) patients treated with intensive chemotherapy followed by autologous stem cell transplantation. CKS1B amplification (3-8 CKS1B signals) was detected in 31of 99 (31%) patients and was associated with deletions of p53 (P = 0.003) and 13q (P = 0.039) but not with… CONTINUE READING