Multiple myeloma

  title={Multiple myeloma},
  author={Laura Marshall},
  journal={Nature Reviews Disease Primers},
  • Laura Marshall
  • Published in
    Nature Reviews Disease…
  • Medicine
  • Primary genetic alterations that lead to the development of MGUS, SMM and, eventually, multiple myeloma include chromosomal translocations and aneuploidy. Chromosomal translocations frequently involve IGH (encoding the immunoglobulin heavy chains) and lead to overexpression of several partner genes, such as NSD2 (also known as MMSET) and CCND1. The most common form of aneuploidy in multiple myeloma is hyperdiploidy and is estimated to occur in ~52% of patients. Secondary genetic alterations… CONTINUE READING

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