Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence.

@article{Borriello1991MultipleMA,
  title={Multiple murine alpha 1-protease inhibitor genes show unusual evolutionary divergence.},
  author={Frank Borriello and Kenneth S. Krauter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 21},
  pages={9417-21}
}
The murine alpha 1-protease inhibitors (alpha 1-PI) are encoded by a small gene family on chromosome 12. Studies of alpha 1-PI and other serine protease inhibitor genes have revealed an unusually high rate of mutation of the reactive centers of the inhibitors. Using a modification of the PCR technique, we have previously identified five distinct alpha 1 PI reactive site sequences present in the genome of C57BL/6 mice. In this report, we use cDNA cloning techniques to demonstrate that all five… CONTINUE READING

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