Multiple multicomponent macrocyclizations including bifunctional building blocks (MiBs) based on Staudinger and Passerini three-component reactions.

@article{Len2008MultipleMM,
  title={Multiple multicomponent macrocyclizations including bifunctional building blocks (MiBs) based on Staudinger and Passerini three-component reactions.},
  author={Fredy Le{\'o}n and Daniel G Rivera and Ludger A. Wessjohann},
  journal={The Journal of organic chemistry},
  year={2008},
  volume={73 5},
  pages={1762-7}
}
Multiple multicomponent macrocyclizations including bifunctional buildings blocks (MiBs) so far have relied almost exclusively on Ugi reactions. The efficient expansion to non-Ugi-MiBs is exemplified by the synthesis of tetra-beta-lactam and bis-alpha-acyloxy carboxamide macrocycles based on multiple Staudinger and Passerini three-component reactions (3CR… CONTINUE READING