Multiple mouse-protective antibodies directed against group B streptococci. Special reference to antibodies effective against protein antigens

@article{Lancefield1975MultipleMA,
  title={Multiple mouse-protective antibodies directed against group B streptococci. Special reference to antibodies effective against protein antigens},
  author={Rebecca Craighill Lancefield and Maclyn Mccarty and William Everly},
  journal={The Journal of Experimental Medicine},
  year={1975},
  volume={142},
  pages={165 - 179}
}
The data presented in this paper establish the finding that multiple specific protective antibodies exist in rabbits in response to immunization with Group B streptococci. The summary in Table I indicates the serological types into which Group B streptococci have been divided on the basis of their antigenic composition. This classification is dependent upon passive protection of mice with antibodies directed against the specific antigens, and types are defined in these terms. Heretofore, it was… 

Tables from this paper

Specificity and protective activity of murine monoclonal antibodies directed against the capsular polysaccharide of type III group B streptococci.
TLDR
41 monoclonal antibodies directed against type III group B streptococci by immunizing Balb/c mice with formalin-killed bacteria are obtained and may be useful, possibly after "humanization" by genetic engineering, for the therapy of neonatal group B Streptococcal infections.
Human monoclonal antibodies to group B streptococcus. Reactivity and in vivo protection against multiple serotypes
TLDR
Data indicate that a single human mAb directed against the group B carbohydrate can protect against GBS infections caused by the different serotypes, useful in the passive immunotherapy of infants infected with GBS.
Mouse-protective antibodies against the Ibc proteins of group B streptococci.
  • L. Bevanger, A. Naess
  • Biology, Medicine
    Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology
  • 1985
TLDR
The antisera showed no protection of animals challenged by a group B streptococcal strain which did not produce any of the Ibc protein antigens, while animals challenged with a strain which produced both of the alpha and beta antIGens were protected by antiserum to the beta antigen.
Functional activity of antibodies to the group B polysaccharide of group B streptococci elicited by a polysaccharide-protein conjugate vaccine
TLDR
That anti-B-TT binds to fewer sites than anti-III-TT may explain the differences in complement activation and in opsonic and protective efficacy of antibodies to group B polysaccharide compared with antibodies to the type-specific capsular poly Saccharide.
Maternal immunization of mice with group B streptococcal type III polysaccharide-beta C protein conjugate elicits protective antibody to multiple serotypes.
TLDR
The beta Cprotein acted as an effective carrier for the type III polysaccharide while simultaneously induced protective immunity against beta C protein--containing strains of group B streptococci.
Estimation of the protective level of human IgG antibody to the type-specific polysaccharide of group B Streptococcus type Ia.
TLDR
Human IgG antibody to the type-specific polysaccharide antigen of group B Streptococcus type Ia in the sera of mice was measured by enzyme-linked immunosorbent assay, indicating the specificity of the antibody and the absence of other humoral factors in protection with this serum.
A monoclonal antibody identifies a protective C-protein alpha-antigen epitope in group B streptococci
TLDR
A novel method for extraction of surface proteins from the A909 (Ia/c) strain of GBS by using mutanolysin is developed and an epitope on the alpha-antigen of the GBS C proteins is identified, identified by protease susceptibility and mouse protection.
Immunochemical characterization of the polysaccharide antigens of group B streptococci.
TLDR
Mouse monoclonal antibodies used in the immunochemical characterization of the polysaccharide antigens of group B streptococci were found to exhibit exclusive specificity for one or the other form of the antigen, and only monoconal antibodies specific for the sialylated Ib poly Saccharide were protective in a mouse model.
Passive protection by human sera in mice against challenge with strains of group B streptococci
TLDR
The findings suggest that the protective activity of human sera is related to specific immunoglobulins against type antigens of GBS, resulting in the reduction of the amounts of IgG, IgA and IgM in normal human serum.
Group B streptococcal vaccines.
TLDR
Once similar results can be documented in women immunized during the last half of pregnancy, efficacy of these candidate GBS polysaccharide vaccines in the prevention of neonatal and young infant GBS disease should be evaluated.
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