Multiple monoclonal B cell expansions and c-myc oncogene rearrangements in acquired immune deficiency syndrome-related lymphoproliferative disorders. Implications for lymphomagenesis

@article{Pelicci1986MultipleMB,
  title={Multiple monoclonal B cell expansions and c-myc oncogene rearrangements in acquired immune deficiency syndrome-related lymphoproliferative disorders. Implications for lymphomagenesis},
  author={P G Pelicci and Daniel M. Knowles and Zalmen A. Arlin and Rosemary Wieczorek and Paul A. Luciw and Dino Dina and Claudio Basilico and Riccardo Dalla-Favera},
  journal={The Journal of Experimental Medicine},
  year={1986},
  volume={164},
  pages={2049 - 2060}
}
AIDS (acquired immune deficiency syndrome) and ARC (AIDS-related complex) are associated with a spectrum of lymphoproliferative disorders ranging from lymphadenopathy syndrome (LAS), an apparently benign polyclonal lymphoid hyperplasia, to B cell non-Hodgkin's lymphoma (B-NHL), i.e., malignant, presumably monoclonal B cell proliferations. To gain insight into the process of lymphomagenesis in AIDS and to investigate a possible pathogenetic relationship between LAS and NHL, we investigated the… CONTINUE READING
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