Multiple molecular determinants for allosteric modulation of alternatively spliced AMPA receptors.

@article{Quirk2003MultipleMD,
  title={Multiple molecular determinants for allosteric modulation of alternatively spliced AMPA receptors.},
  author={Jennifer C Quirk and Eric S. Nisenbaum},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 34},
  pages={10953-62}
}
Positive allosteric regulation of glutamate AMPA receptors involves conformational changes that can attenuate receptor desensitization and enhance ion flux through the channel pore. Many allosteric modulators (e.g., cyclothiazide and aniracetam) preferentially affect the flip (i) or flop (o) alternatively spliced isoform of AMPA receptors, implicating residues in the flip-flop domain as critical determinants of splice variant sensitivity. Indeed, previous mutational analyses have demonstrated… CONTINUE READING

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Isoform-specific early trafficking of AMPA receptor flip and flop variants.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2006
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Mechanism of positive allosteric modulators acting on AMPA receptors.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005
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