Multiple modes of regulation of airway epithelial chloride secretion by extracellular ATP.

@article{Stutts1994MultipleMO,
  title={Multiple modes of regulation of airway epithelial chloride secretion by extracellular ATP.},
  author={M Jackson Stutts and J. Gregory Fitz and Anthony M. Paradiso and Richard C. Boucher},
  journal={The American journal of physiology},
  year={1994},
  volume={267 5 Pt 1},
  pages={C1442-51}
}
Cultured normal and cystic fibrosis (CF) airway epithelia were exposed to 5'-(N-ethylcarboxamido)-adenosine (NECA), ATP, or ionomycin. NECA activated a sustained, 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS)-insensitive Cl- secretory response in normal but not CF, consistent with stimulation of the CF transmembrane conductance regulator (CFTR). In normal and CF, ionomycin or ATP induced Cl- secretion with an initial peak that was inhibited > 50% by DIDS, but in normals there was a… CONTINUE READING