Multiple members of the E2F transcription factor family are the products of oncogenes.

@article{Xu1995MultipleMO,
  title={Multiple members of the E2F transcription factor family are the products of oncogenes.},
  author={Gangfeng Xu and David M. Livingston and Wilhelm Krek},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 5},
  pages={1357-61}
}
The retinoblastoma gene product (pRB) is a known tumor suppressor, capable of arresting growth in mid-to-late G1. Part of its growth suppression action arises from interaction(s) with one or more members of the E2F family of transcription factors. These proteins most likely contribute to progression from G0 to S phase in mammalian cells, and pRB binding most likely inhibits aspects of their suspected growth-promoting function. Given their growth-stimulating potential, we asked whether one or… CONTINUE READING

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