Multiple mechanisms underlying acquired resistance to taxanes in selected docetaxel-resistant MCF-7 breast cancer cells

@inproceedings{Wang2013MultipleMU,
  title={Multiple mechanisms underlying acquired resistance to taxanes in selected docetaxel-resistant MCF-7 breast cancer cells},
  author={Harris Wang and The Vo and Ali Hajar and Sarah Li and Xinmei Chen and Amadeo M Parissenti and David N. Brindley and Zhixiang Wang},
  booktitle={BMC Cancer},
  year={2013}
}
Chemoresistance is a major factor involved in a poor response and reduced overall survival in patients with advanced breast cancer. Although extensive studies have been carried out to understand the mechanisms of chemoresistance, many questions remain unanswered. In this research, we used two isogenic MCF-7 breast cancer cell lines selected for resistance to doxorubicin (MCF-7DOX) or docetaxel (MCF-7TXT) and the wild type parental cell line (MCF-7CC) to study mechanisms underlying acquired… CONTINUE READING
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