Multiple mechanisms of resistance to cis-diamminedichloroplatinum(II) in murine leukemia L1210 cells.

@article{Richon1987MultipleMO,
  title={Multiple mechanisms of resistance to cis-diamminedichloroplatinum(II) in murine leukemia L1210 cells.},
  author={Victoria M. Richon and Nicole Schulte and A. Eastman},
  journal={Cancer research},
  year={1987},
  volume={47 8},
  pages={2056-61}
}
As an experimental model for resistance to cis-diamminedichloroplatinum(II) (cis-DDP), murine leukemia L1210 cells have been exposed to a stepwise increase in cis-DDP concentration to produce a variety of resistant cell lines. Intraspecies hybrids of the sensitive and resistant cells were made to determine whether cis-DDP resistance is a dominant or recessive trait. Hybrid cells displayed a partial degree of resistance as compared to the parental cells. To determine whether this was due to a… CONTINUE READING

From This Paper

Topics from this paper.
86 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 86 extracted citations

Similar Papers

Loading similar papers…