Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis

  title={Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis},
  author={Ramona L. McCaffrey and Justin T. Schwartz and Stephen R. Lindemann and Jessica G. Moreland and Blake W. Buchan and Bradley D. Jones and Lee-Ann H Allen},
  journal={Journal of Leukocyte Biology},
Ft is a facultative intracellular pathogen that infects many cell types, including neutrophils. In previous work, we demonstrated that the type B Ft strain LVS disrupts NADPH oxidase activity throughout human neutrophils, but how this is achieved is incompletely defined. Here, we used several type A and type B strains to demonstrate that Ft‐mediated NADPH oxidase inhibition is more complex than appreciated previously. We confirm that phagosomes containing Ft opsonized with AS exclude… 

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