Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

@article{Campos2012MultipleMI,
  title={Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders},
  author={A. Campos and F. Moreira and F. Gomes and E. Del Bel and F. Guimar{\~a}es},
  journal={Philosophical Transactions of the Royal Society B: Biological Sciences},
  year={2012},
  volume={367},
  pages={3364 - 3378}
}
  • A. Campos, F. Moreira, +2 authors F. Guimarães
  • Published 2012
  • Medicine
  • Philosophical Transactions of the Royal Society B: Biological Sciences
  • Cannabidiol (CBD) is a major phytocannabinoid present in the Cannabis sativa plant. It lacks the psychotomimetic and other psychotropic effects that the main plant compound Δ9-tetrahydrocannabinol (THC) being able, on the contrary, to antagonize these effects. This property, together with its safety profile, was an initial stimulus for the investigation of CBD pharmacological properties. It is now clear that CBD has therapeutic potential over a wide range of non-psychiatric and psychiatric… CONTINUE READING
    211 Citations

    Paper Mentions

    OBSERVATIONAL CLINICAL TRIAL
    The aim of this study is to evaluate the efficacy of oral administration of nabilone or THC/CBD administration in combination with spinal cord stimulation (SCS) in FBSS patients… Expand
    ConditionsFBSS
    InterventionDrug
    Pharmacological properties of cannabidiol in the treatment of psychiatric disorders: a critical overview.
    • 23
    • Highly Influenced
    • PDF
    Beyond the CB1 Receptor: Is Cannabidiol the Answer for Disorders of Motivation?
    • 33
    • PDF
    Evidences for the Anti-panic Actions of Cannabidiol
    • 18
    • PDF

    References

    SHOWING 1-10 OF 161 REFERENCES
    Effect of cannabidiol in a MK-801-rodent model of aspects of Schizophrenia
    • 61
    Phytocannabinoids as novel therapeutic agents in CNS disorders.
    • 192
    • PDF
    Cannabidiol Reverses MK-801-Induced Disruption of Prepulse Inhibition in Mice
    • 127
    • PDF
    Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
    • 542
    • PDF
    Cannabidiol monotherapy for treatment-resistant schizophrenia
    • 143