Multiple mechanisms for choline transport and utilization in Haemophilus influenzae.

@article{Fan2003MultipleMF,
  title={Multiple mechanisms for choline transport and utilization in Haemophilus influenzae.},
  author={X. D. Fan and Christopher D. Pericone and Elena S. Lysenko and Howard Goldfine and Jeffrey N Weiser},
  journal={Molecular microbiology},
  year={2003},
  volume={50 2},
  pages={537-48}
}
Haemophilus influenzae obtains choline from either its growth medium or host cell membrane lipids and expresses it on its lipopolysaccharide (LPS) in the form of phosphorylcholine (ChoP), which contributes to its pathogenesis by mimicry of host cell molecules. Two genes (licB and betT) revealed by whole genomic analysis as encoding potential choline transporters were tested for their role in LPS-ChoP synthesis. The betT gene in H. influenzae is similar to betT in Escherichia coli, which… CONTINUE READING

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