Multiple lysophosphatidic acid acyltransferases in Neisseria meningitidis.

  title={Multiple lysophosphatidic acid acyltransferases in Neisseria meningitidis.},
  author={Giles C Shih and Charlene M Kahler and J S Swartley and Mohammad Majibur Rahman and Jack A Coleman and Russell W Carlson and David S. Stephens},
  journal={Molecular microbiology},
  volume={32 5},
Lysophosphatidic acid (LPA) and phosphatidic acid (PA) are critical phospholipid intermediates in the biosynthesis of cell membranes. In Escherichia coli, LPA acyltransferase (1-acyl-sn-glycerol-3-phosphate acyltransferase; EC catalyses the transfer of an acyl chain from either acyl-coenzyme A or acyl-acyl carrier protein onto LPA to produce PA. While E. coli possesses one essential LPA acyltransferase (PlsC), Neisseria meningitidis possesses at least two LPA acyltransferases. This… CONTINUE READING
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