Multiple loss of effector cell functions in FcR gamma-deficient mice.

  • T. Takai
  • Published 1996 in International reviews of immunology

Abstract

Immunoglobulin Fc receptor (FcR) gamma subunit is a component of low affinity receptor for IgG, Fc gamma RIII, as well as high affinity receptor for IgE, Fc epsilon RI. This subunit is required for efficient surface expression of these FcRs on various cells in immune system. The FcR gamma-deficient mice, generated by gene targeting in embryonic stem cells… (More)

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