Multiple loci identified in a genome-wide association study of prostate cancer

  title={Multiple loci identified in a genome-wide association study of prostate cancer},
  author={Gilles D. Thomas and Kevin B. Jacobs and Meredith Yeager and Peter Kraft and Sholom Wacholder and Nick Orr and Kai Yu and Nilanjan Chatterjee and Robert Welch and Amy A Hutchinson and Andrew Crenshaw and G{\'e}raldine Cancel-Tassin and Brian Staats and Zhaoming Wang and Jesus Gonzalez-Bosquet and Jun Fang and Xiang Deng and Sonja I. Berndt and Eugenia E. Calle and Heather Spencer Feigelson and Michael J. Thun and Carmen Rodr{\'i}guez and Demetrius Albanes and Jarmo R. K. Virtamo and Stephanie J. Weinstein and Fredrick R. Schumacher and Edward L. Giovannucci and Walter C. Willett and Olivier Cussenot and Antoine Val{\'e}ri and Gerald L. Andriole and E. David Crawford and Margaret A. Tucker and Daniela S. Gerhard and Joseph F. Jr. Fraumeni and Robert N. Hoover and Richard B. Hayes and David J. Hunter and Stephen J. Chanock},
  journal={Nature Genetics},
We followed our initial genome-wide association study (GWAS) of 527,869 SNPs on 1,172 individuals with prostate cancer and 1,157 controls of European origin—nested in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial prospective study—by testing 26,958 SNPs in four independent studies (total of 3,941 cases and 3,964 controls). In the combined joint analysis, we confirmed three previously reported loci (two independent SNPs at 8q24 and one in HNF1B (formerly known as TCF2… 

Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population

Five new loci for prostate cancer susceptibility are reported here, at 5p15 (λ-corrected probability PGC = 3.9 × 10−18), GPRC6A/RFX6 (PGC = 1.6 ×10−12), 13q22 ( PGC = 2.8 × 10–10−9), C2orf43 (PGD = 7.5 × 10.–8) and FOXP4 (PGE = 7−8).

Two Independent Prostate Cancer Risk–Associated Loci at 11q13

The prostate cancer association at these two 11q13 loci was unlikely confounded by prostate-specific antigen (PSA) detection bias because neither SNP was associated with PSA levels in controls and both remained significant after adjusting for the other locus and study population.

Genome-wide association study identifies new prostate cancer susceptibility loci.

A new susceptibility locus associated with overall PrCa risk at 2q37.3 is identified and a locus suggested by an earlier GWAS at 12q13 is confirmed, although it is unclear whether these or other loci are differentially associated with PrCa subtypes.

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

A large meta-analysis combining genome-wide and custom high-density genotyping array data identifies 63 new susceptibility loci for prostate cancer, enhancing fine-mapping efforts and providing insights into the underlying biology of PrCa1.

Genome-Wide Association Study Identifies a Possible Susceptibility Locus for Endometrial Cancer

Background: Genome-wide association studies (GWAS) have identified more than 100 genetic loci for various cancers. However, only one is for endometrial cancer. Methods: We conducted a three-stage

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

The study is extended to evaluate promising associations in a second stage in which 43,671 SNPs are genotyped in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies.

A novel prostate cancer susceptibility locus at 19q13.

A fine-mapping study in a 110-kb region at 19q13 among CAPS and JHH study populations revealed that rs887391 was the most strongly associated SNP in the region.

12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population

A GWAS and replication study using a large Japanese cohort of prostate cancer patients is performed, finding 12 new susceptibility loci, and identifying a polygenic risk for Japanese prostate cancer.

Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese

In a meta-analysis of the previous GWAS and the replication studies, three new loci reached genome-wide significance on chromosomes 11q12, 10q26 and 3p11 and should provide additional insight into the pathogenesis of prostate cancer and emphasizes the importance of conducting GWAS in diverse populations.

Refining the Prostate Cancer Genetic Association within the JAZF1 Gene on Chromosome 7p15.2

Background: Genome-wide association studies have identified multiple genetic variants associated with susceptibility to prostate cancer (PrCa). In the two-stage Cancer Genetic Markers of



Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

Observations indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry, and it is estimated that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked byrs1447295.

Genome-wide association study identifies novel breast cancer susceptibility loci

To identify further susceptibility alleles, a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls was conducted, followed by a third stage in which 30 single nucleotide polymorphisms were tested for confirmation.

Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24

Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, markers in chromosomal region 8q24 associated with colorectal cancer were identified and this locus has been implicated in prostate cancer.

Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes

Results from eight case-control groups demonstrate that this variant in TCF2 (HNF1β), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5, confers protection against type 2 diabetes.

The complex genetic epidemiology of prostate cancer.

  • D. Schaid
  • Biology, Medicine
    Human molecular genetics
  • 2004
This review provides updates on recent developments, and a broad view of the disparate findings from different linkage studies for prostate cancer susceptibility, and recent findings that Gleason's grade, a measure of aggressiveness of prostate cancer, is linked to several genomic regions are reviewed.

A common variant associated with prostate cancer in European and African populations

Allele −8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US, and the association was replicated in an African American case- control group with a similar OR, leading to a greater estimated PAR.

Multiple regions within 8q24 independently affect risk for prostate cancer

Seven prostate cancer risk variants are identified, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (P = 7.9 × 10−19 for the strongest association), and common genotypes that span a more than fivefold range of susceptibility to cancer in some populations are defined.

Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men

Admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it and finding that the previously described alleles do not explain more than a fraction of the admixture signal.

A genome-wide association study of global gene expression

A global map of the effects of polymorphism on gene expression in 400 children from families recruited through a proband with asthma is created and a downloadable database is created to facilitate use of the findings in the mapping of complex disease loci.

Molecular genetics of prostate cancer.