Multiple loci identified in a genome-wide association study of prostate cancer

@article{Thomas2008MultipleLI,
  title={Multiple loci identified in a genome-wide association study of prostate cancer},
  author={Gilles D. Thomas and Kevin B. Jacobs and Meredith Yeager and Peter Kraft and Sholom Wacholder and Nick Orr and Kai Yu and Nilanjan Chatterjee and Robert Welch and Amy A Hutchinson and Andrew Crenshaw and G{\'e}raldine Cancel-Tassin and Brian Staats and Zhaoming Wang and Jesus Gonzalez-Bosquet and Jun Fang and Xiang Deng and Sonja I. Berndt and Eugenia E. Calle and Heather Spencer Feigelson and Michael J. Thun and Carmen Rodr{\'i}guez and Demetrius Albanes and Jarmo Virtamo and Stephanie J. Weinstein and Fredrick R. Schumacher and Edward L. Giovannucci and Walter C. Willett and Olivier Cussenot and Antoine Val{\'e}ri and Gerald L. Andriole and E. David Crawford and Margaret A. Tucker and Daniela S. Gerhard and Joseph F. Jr. Fraumeni and Robert N. Hoover and Richard B. Hayes and David J. Hunter and Stephen J. Chanock},
  journal={Nature Genetics},
  year={2008},
  volume={40},
  pages={310-315}
}
We followed our initial genome-wide association study (GWAS) of 527,869 SNPs on 1,172 individuals with prostate cancer and 1,157 controls of European origin—nested in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial prospective study—by testing 26,958 SNPs in four independent studies (total of 3,941 cases and 3,964 controls). In the combined joint analysis, we confirmed three previously reported loci (two independent SNPs at 8q24 and one in HNF1B (formerly known as TCF2… Expand

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