Multiple limbic regions mediate the disruption of prepulse inhibition produced in rats by the noncompetitive NMDA antagonist dizocilpine.

@article{Bakshi1998MultipleLR,
  title={Multiple limbic regions mediate the disruption of prepulse inhibition produced in rats by the noncompetitive NMDA antagonist dizocilpine.},
  author={Vikram Bakshi and Mark A. Geyer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 20},
  pages={8394-401}
}
Prepulse inhibition (PPI), a phenomenon in which a weak prestimulus decreases the startle response to an intense stimulus, provides an operational measure of sensorimotor gating (a process by which an organism filters sensory information) and is diminished in schizophrenia and schizotypal patients. The psychotomimetic phencyclidine and its potent congener dizocilpine are noncompetitive antagonists of the NMDA receptor complex, and they disrupt PPI in rodents, mimicking the clinically observed… CONTINUE READING

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Effects of N-allylnormetazocine (SKF 10,047), phencyclidine, and other psychomotor stimulants in the rat following 6-hydroxydopamine lesion of the ventral tegmental area

  • ED French
  • Neuropharmacology
  • 1986
Highly Influential
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