Multiple ligand binding sites on domain seven of human complement factor H.

@article{Giannakis2001MultipleLB,
  title={Multiple ligand binding sites on domain seven of human complement factor H.},
  author={Eleni Giannakis and Dean A. Male and Rebecca J. Ormsby and Carolyn Mold and T Sakari Jokiranta and Shoba Ranganathan and David Lee Gordon},
  journal={International immunopharmacology},
  year={2001},
  volume={1 3},
  pages={433-43}
}
Foreign particles and damaged host cells can activate the complement system leading to their destruction by the host defense system. Factor H (fH) plays a vital role in restricting complement activation on host cells through interactions with polyanions such as heparin, while allowing activation to proceed on foreign surfaces. Complement activation by damaged host cells is also down regulated by fH, which is localized to injured areas through interactions with C-reactive protein (CRP). A number… CONTINUE READING