Multiple label-free detection of antigen-antibody reaction using localized surface plasmon resonance-based core-shell structured nanoparticle layer nanochip.

@article{Endo2006MultipleLD,
  title={Multiple label-free detection of antigen-antibody reaction using localized surface plasmon resonance-based core-shell structured nanoparticle layer nanochip.},
  author={Tatsuro Endo and Kagan Kerman and Naoki Nagatani and Ha Minh Hiepa and Do-kyun Kim and Yuji Yonezawa and Koichi Nakano and Eiichi Tamiya},
  journal={Analytical chemistry},
  year={2006},
  volume={78 18},
  pages={
          6465-75
        }
}
In this research, a localized surface plasmon resonance (LSPR)-based bioanalysis method for developing multiarray optical nanochip suitable for screening bimolecular interactions is described. LSPR-based label-free monitoring enables to solve the problems of conventional methods that require large sample volumes and time-consuming labeling procedures. We developed a multiarray LSPR-based nanochip for the label-free detection of proteins. The multiarray format was constructed by a core-shell… CONTINUE READING
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