Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array.

@article{McKendry2002MultipleLB,
  title={Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array.},
  author={Rachel McKendry and Jiayun Zhang and Youri Arntz and Torsten Strunz and Martin Hegner and Hans Peter Lang and Marko K. Baller and Ulrich Certa and Ernst Meyer and H J G{\"u}ntherodt and Christoph Gerber},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 15},
  pages={9783-8}
}
We report a microarray of cantilevers to detect multiple unlabeled biomolecules simultaneously at nanomolar concentrations within minutes. Ligand-receptor binding interactions such as DNA hybridization or protein recognition occurring on microfabricated silicon cantilevers generate nanomechanical bending, which is detected optically in situ. Differential measurements including reference cantilevers on an array of eight sensors can sequence-specifically detect unlabeled DNA targets in 80-fold… CONTINUE READING

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