Multiple knockout mouse models reveal lincRNAs are required for life and brain development

  title={Multiple knockout mouse models reveal lincRNAs are required for life and brain development},
  author={Martin Sauvageau and Loyal A Goff and Simona Lodato and Boyan Bonev and Abigail F. Groff and Chiara Gerhardinger and Diana B Sanchez-Gomez and Ezgi Hacisuleyman and Eric K. Y. Li and M. Anne Spence and Stephen C Liapis and William Mallard and Michael B. Morse and Mavis R. Swerdel and Michael F D’Ecclessis and Jennifer C. Moore and Venus Lai and Guochun Gong and George D. Yancopoulos and D. A. Frendewey and Manolis Kellis and Ronald P. Hart and David M. Valenzuela and Paola Arlotta and John L Rinn},
Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs in various physiological conditions, we have developed a collection of 18 lncRNA knockout strains in which the locus is maintained transcriptionally active. Initial characterization revealed peri- and postnatal lethal phenotypes in three mutant strains (Fendrr, Peril, and Mdgt… CONTINUE READING
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