Multiple isotopic labels for quantitative mass spectrometry.

  title={Multiple isotopic labels for quantitative mass spectrometry.},
  author={Cain Morano and Xin Zhang and Lloyd D Fricker},
  journal={Analytical chemistry},
  volume={80 23},
Quantitative mass spectrometry is often performed using isotopically labeled samples. Although the 4-trimethylammoniumbutyryl (TMAB) labels have many advantages over other isotopic tags, only two forms have previously been synthesized (i.e., a heavy form containing nine deuteriums and a light form without deuterium). In the present report, two additional forms containing three and six deuteriums have been synthesized and tested. These additional isotopic tags perform identically to the… CONTINUE READING