Multiple isoforms of the tumor suppressor myopodin are simultaneously transcribed in cancer cells.

@article{Ganck2008MultipleIO,
  title={Multiple isoforms of the tumor suppressor myopodin are simultaneously transcribed in cancer cells.},
  author={Ariane De Ganck and Veerle De Corte and An Staes and Kris Gevaert and Jo{\"e}l Vandekerckhove and Jan Gettemans},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={370 2},
  pages={269-73}
}
Expression of myopodin, an actin associated protein, is frequently lost in invasive prostate cancers due to partial or complete deletion of the gene. Screening of public databases reveals that two human myopodin isoforms have been proposed. Remarkably both isoforms deviate profoundly from the human or mouse isoforms examined to date. Here, we investigated expression of human myopodin. Rapid amplification of cDNA ends revealed a new myopodin transcript, hitherto unpredicted by public databases… CONTINUE READING