Multiple isoforms of the ryanodine receptor are expressed in rat pancreatic acinar cells.

@article{Fitzsimmons2000MultipleIO,
  title={Multiple isoforms of the ryanodine receptor are expressed in rat pancreatic acinar cells.},
  author={Timothy J. Fitzsimmons and I. Ya. Gukovsky and J. A. Mcroberts and E. R. Rodriguez and F Anthony Lai and S. J. Pandol},
  journal={The Biochemical journal},
  year={2000},
  volume={351 Pt 1},
  pages={
          265-71
        }
}
  • Timothy J. Fitzsimmons, I. Ya. Gukovsky, +3 authors S. J. Pandol
  • Published in The Biochemical journal 2000
  • Medicine, Biology
  • Regulation of cytosolic Ca(2+) is important for a variety of cell functions. The ryanodine receptor (RyR) is a Ca(2+) channel that conducts Ca(2+) from internal pools to the cytoplasm. To demonstrate the presence of the RyR in the pancreatic acinar cell, we performed reverse transcriptase (RT)-PCR, Western blot, immunocytochemistry and microscopic Ca(2+)-release measurements on these cells. RT-PCR showed the presence of mRNA for RyR isoforms 1, 2 and 3 in both rat pancreas and dispersed… CONTINUE READING

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