Multiple intracellular pathways induce expression of a zinc-finger encoding gene (EGR1): relationship to activation of the Na/H exchanger.

@article{Jamieson1989MultipleIP,
  title={Multiple intracellular pathways induce expression of a zinc-finger encoding gene (EGR1): relationship to activation of the Na/H exchanger.},
  author={Graham A Jamieson and Rick Mayforth and Mitchel L Villereal and Vikas P Sukhatme},
  journal={Journal of cellular physiology},
  year={1989},
  volume={139 2},
  pages={262-8}
}
Intracellular pathways that rapidly stimulate the expression of a mitogen-inducible, zinc-finger encoding gene, EGR1 (Sukhatme et al., Cell 53:37-43), have been characterized in two human fibroblasts strains (WI-38 and HSWP). Serum and epidermal growth factor (EGF) were each found to strongly stimulate EGR1 expression in both cell types. Comparably high levels of expression could also be induced by treatment with the phorbol ester TPA. In cells rendered deficient in PK-C, serum and EGF were… CONTINUE READING