Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif.

@article{Flynn1998MultipleIO,
  title={Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif.},
  author={P Flynn and Harry Mellor and Ruth Palmer and George N Panayotou and Peter J Parker},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 5},
  pages={2698-705}
}
PRK1 (PKN) is a serine/threonine kinase that has been shown to be activated by RhoA (Amano, M., Mukai, H., Ono, Y., Chihara, K., Matsui, T., Hamajima, Y., Okawa, K., Iwamatsu, A., and Kaibuchi, K. (1996) Science 271, 648-650). Detailed analysis of the PRK1 region involved in RhoA binding has revealed that two homologous sequences within the HR1 domain (HR1a and HR1b) both bind to RhoA; the third repeat within this domain, HR1cPRK1, does not bind RhoA. The related HR1 motif is also found to… CONTINUE READING