Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.

@article{Patrinos2004MultipleIB,
  title={Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.},
  author={George P. Patrinos and Mariken de Krom and Ernie de Boer and An Langeveld and A M Ali Imam and John Strouboulis and Wouter de Laat and Frank G. Grosveld},
  journal={Genes & development},
  year={2004},
  volume={18 12},
  pages={1495-509}
}
The human beta-globin locus control region (LCR) is required for the maintenance of an open chromatin configuration of the locus. It interacts with the genes and the hypersensitive regions flanking the locus to form an active chromatin hub (ACH) transcribing the genes. Proper developmental control of globin genes is largely determined by gene proximal regulatory sequences. Here, we provide the first functional evidence of the role of the most active sites of the LCR and the promoter of the beta… CONTINUE READING

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