Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer.

@article{Yang2006MultipleIO,
  title={Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer.},
  author={Zheng Quan Yang and Katie L. Streicher and Michael Edward Ray and Judith L. Abrams and Stephen P Ethier},
  journal={Cancer research},
  year={2006},
  volume={66 24},
  pages={
          11632-43
        }
}
The 8p11-p12 genomic region is amplified in 15% of breast cancers and harbors several candidate oncogenes. However, functional evidence for a transforming role for these genes is lacking. We identified 21 genes from this region as potential oncogenes based on statistical association between copy number and expression. We further showed that three of these genes (LSM1, BAG4, and C8orf4) induce transformed phenotypes when overexpressed in MCF-10A cells, and overexpression of these genes in… CONTINUE READING

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