Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome.

@article{Chen1999MultipleIF,
  title={Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome.},
  author={Huawei Chen and Shi Qiang Wei and Alan N. Engelman},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 24},
  pages={17358-64}
}
Mu-mediated polymerase chain reaction footprinting was used to investigate the protein-DNA structure of human immunodeficiency virus type I (HIV-I) preintegration complexes. Preintegration complexes were partially purified from cells after using an established coculture infection technique as well as a novel technique using cell-free supernatant from transfected cells as the source of virus. Footprinting revealed that bound proteins protected the terminal 200-250 base pairs of each viral end… CONTINUE READING
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