Multiple inputs control sulfur-containing amino acid synthesis in Saccharomyces cerevisiae

@inproceedings{Sadhu2014MultipleIC,
  title={Multiple inputs control sulfur-containing amino acid synthesis in Saccharomyces cerevisiae},
  author={Meru J Sadhu and James J. Moresco and Anjali D Zimmer and John R. Yates and Jasper Rine},
  booktitle={Molecular biology of the cell},
  year={2014}
}
In Saccharomyces cerevisiae, transcription of the MET regulon, which encodes the proteins involved in the synthesis of the sulfur-containing amino acids methionine and cysteine, is repressed by the presence of either methionine or cysteine in the environment. This repression is accomplished by ubiquitination of the transcription factor Met4, which is carried out by the SCF(Met30) E3 ubiquitin ligase. Mutants defective in MET regulon repression reveal that loss of Cho2, which is required for the… CONTINUE READING

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